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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Synaptic augmentation ： ウィキペディア英語版 Synaptic augmentation Augmentation is one of four components of short-term synaptic plasticity that increases the probability of releasing synaptic vesicles during and after repetitive stimulation such that : During a train of impulses the enhancement of synaptic strength due to the underlying component $A^$ * that gives rise to augmentation can be described by :$\backslash frac\; =\; J(t)a^$ * - k_A^ * where $J(t)$ is the unit impulse function at the time of stimulation, $a^$ * is the incremental increase in $A^$ * with each impulse, and $k\_$ is the rate constant for the loss of $A^$ *. During a stimulus train the magnitude of augmentation added by each impulse, a *, can increase during the train such that :$a^$ * = a^ *_0 Z^ where $a^$ *_0 is the increment added by the first impulse of the train, $Z$ is a constant that determines the increase in $a^$ * with each impulse, $S$ is the stimulation rate, and $T$ is the duration of stimulation. Augmentation is differentiated from the three other components of enhancement by its time constant of decay. This is shown in Table 1 where the first and second components of facilitation, F1 and F2, decay with time constants of about 50 and 300 ms, and potentiation, P, decays with a time constant than ranges from tens of seconds to minutes depending on the duration of stimulation. Also included in the table are two components of depression D1 and D2, along with their associated decay time constants of recovery decay back to normal. Depression at some synapses may arise from depletion of synaptic vesicles available for release. Depression of synaptic vesicle release may mask augmentation because of overlapping time courses. Also included in the table is the fraction change in transmitter release arising from one impulse. A magnitude of 0.8 would increase transmitter release 80%. †The magnitude of augmentation added by each impulse can increase during the train. ‡The time constant of P can increase with repetitive stimulation. The balance between various components of enhancement and depression at the mammalian synapse is affected by temperature so that maintenance of the components of enhancement is greatly reduced at temperatures lower than physiological. During repetitive stimulation at 23 °C components of depression dominate synaptic release, whereas at 33–38 °C synaptic strength increases due to a shift towards components of enhancement. ==References== *Klyachko V.A. and Stevens C.F. (2006) Temperature-dependent shift of balance among the components of short-term plasticity in hippocampal synapses. J. Neurosci. 26, 6945-6957. *Magleby K.L. and Zengel J.E. (1976a) Augmentation: A process that acts to increase transmitter release at the frog neuromuscular junction. J. Physiol (Lond.) 257, 449-470. *Magleby KL and Zengel J.E. (1976b) Long term changes in augmentation, potentiation, and depression of transmitter release as a function of repeated synaptic activity at the frog neuromuscular junction. J. Physiol. (Lond.) 257, 471-494. *Magleby KL and Zengel J.E. (1976c) Stimulation-induced factors which affect augmentation and potentiation of transmitter release at the neuromuscular junction. J. Physiol. (Lond.) 260, 687-717. *Magleby K.L. and Zengel J.E. (1982) A quantitative description of stimulation-induced changes in transmitter release at the frog neuromuscular junction. J. Gen. Physiol. 80, 613-638. *Stevens C.F. and Wesseling J.F. (1999a) Augmentation is a potentiation of the exocytotic process. Neuron 22, 139-146. *Wesseling J.F. and Lo D.C. (2002) Limit on the role of activity in controlling the release-ready supply of synaptic vesicles. J. Neurosci. 22, 9708-9720. *Garcia-Perez E, Wesseling JF (2008) Augmentation controls the fast rebound from depression at excitatory hippocampal synapses. J. Neurophys. 99: 1770-1786 *Zengel J.E. and Magleby K.L. (1977) Transmitter release during repetitive stimulation: selective changes produced by Sr2+ and Ba2+. Science 197, 67-69. *Zengel J.E. and Magleby K.L. (1981) Changes in miniature endplate potential frequency during repetitive nerve stimulation in the presence of Ca2+, Ba2+, and Sr2+ at the frog neuromuscular junction. J. Gen. Physiol. 77, 503-529. *Zengel J.E. and Magleby K.L. (1982) Augmentation and facilitation of transmitter release. A quantitative description at the frog neuromuscular junction. J. Gen. Physiol. 80, 583-611. *Zengel J.E., Magleby K.L., Horn J.P., McAfee D.A., and Yarowsky P.J. (1980) Facilitation, augmentation, and potentiation of synaptic transmission at the superior cervical ganglion of the rabbit. J. Gen. Physiol. 76, 213-231. *Zucker R.S. and Regehr W.G. (2002) Short-term synaptic plasticity. Annu. Rev. Physiol. 64, 355-405. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Synaptic augmentation」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.